Breaking news: T antigen announces “I don’t need no activator E2Fs”

Over several decades of cancer research, T antigen, a.k.a MAMU, has proven itself to be a strong activator of cellular transformation. In a stunning finding revealed by Tushar Gupta and colleagues (in a recentĀ  Journal of Virology paper), SV40 T antigen declares that it does not need activator E2Fs to cause cellular transformation. T antigen said, “I have been telling you all along. I don’t need no activator E2Fs!”

Cell-type specificity rules!

The current model for tumorigenesis is that mutations in genes alter gene expression and/or the normal function of proteins or gene expression. Correspondingly, this predicts that an oncogene such as T antigen would have the same effects in different cell types. However, experiments performed by Mayte Saenz-Robles and colleagues challenge this prediction. In a paper published in Molecular Cancer Research, they describe how a truncated form of T antigen (aka MAMU) called N136 is able to form adenomatous polyps in the digestive tract when expressed in progenitor crypt cells while only causing hyperplasia and dysplasia in the villi. Isn’t cell-type specificity cool?!