Publications

  • 2017
    • Starrett, G. J., C. Marcelus, P. G. Cantalupo, J. P. Katz, J. Cheng, K. Akagi, M. Thakuria, G. Rabinowits, L. C. Wang, D. E. Symer, J. M. Pipas, R. S. Harris, and J. A. DeCaprio. 2017. Merkel cell polyomavirus exhibits dominant control of the tumor genome and transcriptome in virus-associated Merkel cell carcinoma. mBio e8(1): e02079-16. PMID: 28049147. PMC5210499
  • 2016
    • Kent, L. N., J. B. Rakijas, S. K. Pandit, B. Westendorp, H. Z. Chen, J. T. Huntington, X. Tang, S. Bae, A. Srivastava, S. Senapati, C. Koivisto, C. K. Martin, M. C. Cuitino, M. Perez, J. M. Clouse, V. Chokshi, N. Shinde, R. Kladney, D. Sun, A. Perez-Castro, R. B. Matondo, S. Nantasanti, M. Mokry, K. Huang, R. Machiraju, S. Fernandez, T. J. Rosol, V. Coppola, K. S. Pohar, J. M. Pipas, C. R. Schmidt, A. de Bruin, and G. Leone. 2016. E2F8 mediates tumor suppression in postnatal liver development. J. Clin. Invest. 126: 2955-2969. PMID: 27454291
    • Buck, C. B., K. Van Doorslaer,, A. Peretti, E. M. Geoghegan, M. J. Tisza, P. An, J. P. Katz, J. M. Pipas, A. A. McBride, A. C. Camus, A. J. McDermott, J. A. Dill, E. Delwart, T. F. Ng, K. Farkas, C. Austin, S. Kraberger, W. Davison, D. V. Pastrana, and A. Varsani. 2016. The ancient evolutionary history of polyomaviruses. PLoS Pathogens 12: e1005574. PMID: 27093155.
    • Tang, X., H. Liu, A. Srivastava, T. Pecot, Z. Chen, Q. Wang, K. Huang, M. T. Saenz-Robles, P. Cantalupo, J. Pipas, and G. Leone. 2016. Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice. Sci. Data 3: 160008. PMID: 26881867. PMC: PMC4755127
  • 2015
    • Gupta, T. M. T. Saenz-Robles, R. M. Schowalter, C. B. Buck, and J. M. Pipas. 2015. Expression of the small T antigen of Lymphotropic Papovavirus is sufficient to transform primary mouse embryo fibroblasts. Virology 487: 112-120. PMID: 26517398. PMC: PMC4679568
    • Han HS, Cantalupo PG, Rotem A, Cockrell SK, Carbonnaux M, Pipas JM, Weitz DA. Whole-Genome Sequencing of a Single Viral Species from a Highly Heterogeneous Sample. Angew Chem Int Ed Engl. 2015 Aug 28. doi: 10.1002/anie.201507047. PubMed PMID: 26316088.
    • Tao Y, Rotem A, Zhang H, Chang CB, Basu A, Kolawole AO, Koehler SA, Ren Y, Lin JS, Pipas JM, Feldman AB, Wobus CE, Weitz DA. Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics. Lab Chip. 2015 Aug 25. PubMed PMID: 26304791.
    • Tao Y, Rotem A, Zhang H, Cockrell SK, Koehler S, Chang CB, Ung LW, Cantalupo P, Ren Y, Lin JS, Feldman AB, Wobus CE, Pipas JM, Weitz D. Artifact-free Quantification and Sequencing of Rare Recombinant Viruses Using Drop-based microfluidics. Chembiochem. 2015 Aug 6. doi: 10.1002/cbic.201500384. PubMed PMID: 26247541.
    • Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, Reyes S, Fackler N, Bajwa A, Kladney R, Koivisto C, Chen Z, Wang Q, Huang K, Machiraju R, Sáenz-Robles MT, Cantalupo P, Pipas JM, Leone G. Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015 Aug;17(8):1036-48. doi: 10.1038/ncb3210. PubMed PMID: 26192440; PubMed Central PMCID: PMC4526313.
    • Zhang H, Cockrell SK, Kolawole AO, Rotem A, Serohijos AW, Chang CB, Tao Y, Mehoke TS, Han Y, Lin JS, Giacobbi NS, Feldman AB, Shakhnovich E, Weitz DA, Wobus CE, Pipas JM. Isolation and analysis of rare norovirus recombinants from co-infected mice using drop-based microfluidics. J. Virol. August 2015 vol. 89 no. 15 7722-7734. PubMed PMID: 25972549.
    • An P, Brodsky JL, Pipas JM. The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens. Arch Biochem Biophys. 2015 Mar 6;573:23-31. doi: 10.1016/j.abb.2015.02.033. PubMed PMID: 25752954.
    • Gupta T, Sáenz Robles MT, Pipas JM. Cellular Transformation of Mouse Embryo Fibroblasts in the Absence of Activator E2Fs. J Virol. 2015 May 1;89(9):5124-33. doi: 10.1128/JVI.03578-14. PubMed PMID: 25717106.
    • Cantalupo PG, Katz JP, Pipas JM. HeLa Nucleic Acid Contamination in The Cancer Genome Atlas Leads to the Misidentification of Human Papillomavirus 18. J Virol. 2015 Apr 15;89(8):4051-7. doi: 10.1128/JVI.03365-14. PubMed PMID: 25631090.
    • Giacobbi NS, Gupta T, Coxon AT, Pipas JM. Polyomavirus T antigens activate an antiviral state. Virology. 2015 Feb;476:377-85. doi: 10.1016/j.virol.2014.12.032. PubMed PMID: 25589241.
  • 2014
    • Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorg Med Chem. 2014 Nov 15;22(22):6490-502. PubMed PMID: 25440730; PubMed Central PMCID: PMC4293281.
    • Katz JP, Pipas JM. SummonChimera infers integrated viral genomes with nucleotide precision from NGS data. BMC Bioinformatics. 2014 Oct 22;15(1):348. [Epub ahead of print] PubMed PMID: 25331652
    • Seneca NT, Sáenz Robles MT, Pipas JM. Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation. Virology. 2014 Aug 14;468-470C:47-56. doi: 10.1016/j.virol.2014.07.038. [Epub ahead of print] PubMed PMID: 25129438.
    • Saenz Robles MT, Chong JL, Koivisto C, Trimboli A, Liu H, Leone G, Pipas JM. Viral Oncogene Expression in the Stem/Progenitor Cell Compartment of the Mouse Intestine Induces Adenomatous Polyps. Mol Cancer Res. 2014 Jul 3. pii:molcanres.0166.2014. [Epub ahead of print] PubMed PMID: 24994749.
    • Yu X, Bian X, Throop A, Song L, Moral LD, Park J, Seiler C, Fiacco M, Steel J, Hunter P, Saul J, Wang J, Qiu J, Pipas JM, LaBaer J. Exploration of panviral proteome: high-throughput cloning and functional implications in virus-host interactions. Theranostics. 2014 Jun 6;4(8):808-22. doi: 10.7150/thno.8255.
      eCollection 2014. PubMed PMID: 24955142; PubMed Central PMCID: PMC4063979.
    • Forero A, Giacobbi NS, McCormick KD, Gjoerup OV, Bakkenist CJ, Pipas JM, Sarkar SN. Simian Virus 40 Large T Antigen Induces IFN-Stimulated Genes through ATR Kinase. J Immunol. 2014 May 5. [Epub ahead of print] PubMed PMID: 24799566.
    • Mishra N, Pereira M, Rhodes RH, An P, Pipas JM, Jain K, Kapoor A, Briese T, Faust PL, Lipkin WI. Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy. J Infect Dis. 2014 May 1. [Epub ahead of print] PubMed PMID: 24795478.
    • Cecchini MJ, Thwaites M, Talluri S, Macdonald JI, Passos DT, Chong JL, Cantalupo P, Stafford P, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA. A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice. Mol Cell Biol. 2014 Mar 24. PMID: 24662053
    • Kolawole AO, Li M, Xia C, Fischer AE, Giacobbi NS, Rippinger CM, Proescher JB, Wu SK, Bessling SL, Gamez M, Yu C, Zhang R, Mehoke TS, Pipas JM, Wolfe JT, Lin JS, Feldman AB, Smith TJ, Wobus CE. Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization. J Virol. 2014 Apr;88(8):4543-57. doi: 10.1128/JVI.03685-13. Epub 2014 Feb 5. PMID: 24501415
  • 2013
    • Sáenz Robles MT, Shivalila C, Wano J, Sorrells S, Roos A, Pipas JM. Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells. J Virol. 2013 Dec;87(24):13499-509. doi: 10.1128/JVI.02658-13. Epub 2013 Oct 2. PMID: 24089570
  • 2012
    • An P, Sáenz Robles MT, Pipas JM. Large T antigens of polyomaviruses: amazing molecular machines. Annu Rev Microbiol. 2012 Oct 13;66:213-36. PMID: 22994493 (PDF)
    • Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res. 2012 Aug 7;96(1):70-81. PMID: 22898086.
    • Williams CK, Vaithiyalingam S, Hammel M, Pipas J, Chazin WJ. Binding to retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen. Arch Biochem Biophys. 2012 Feb 15;518(2):111-8. Epub 2011 Dec 29. PubMed PMID: 22227098; PubMed Central PMCID: PMC3279518.
  • 2011
    • Sáenz Robles MT, Case A, Chong JL, Leone G, Pipas JM. The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. PLoS One. 2011;6(10):e26019. Epub 2011 Oct 12. PubMed PMID: 22022495; PubMed Central PMCID: PMC3192141 (PDF).
    • Cantalupo PG, Calgua B, Zhao G, Hundesa A, Wier AD, Katz JP, Grabe M, Hendrix RW, Girones R, Wang D, Pipas JM. Raw sewage harbors diverse viral populations. MBio. 2011 Oct 4;2(5). pii: e00180-11. doi: 10.1128/mBio.00180-11. Print 2011. PubMed PMID: 21972239; PubMed Central PMCID: PMC3187576 (PDF) (Data).
  • Pre 2011
  • Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G. Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45. Epub 2010 Dec 23. PubMed PMID: 21185283.
  • Rathi AV, Cantalupo PG, Sarkar SN, Pipas JM. Induction of interferon-stimulated genes by Simian virus 40 T antigens. Virology. 2010 Oct 25;406(2):202-11. Epub 2010 Aug 7. PubMed PMID: 20692676; PubMed Central PMCID: PMC2939315.
  • Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009 Dec 17;462(7275):930-4. PubMed PMID: 20016602; PubMed Central PMCID: PMC2806193.
  • Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009 Dec;83(24):13019-25. Epub 2009 Oct 7. PubMed PMID: 19812170; PubMed Central PMCID: PMC2786824.
  • Rathi AV, Sáenz Robles MT, Cantalupo PG, Whitehead RH, Pipas JM. Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway. J Virol. 2009 Sep;83(18):9521-31. Epub 2009 Jul 1. PubMed PMID: 19570859; PubMed Central PMCID: PMC2738269.
  • Ahuja D, Rathi AV, Greer AE, Chen XS, Pipas JM. A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation. J Virol. 2009 Sep;83(17):8781-8. Epub 2009 Jun 24. PubMed PMID: 19553311; PubMed Central PMCID: PMC2738162.
  • Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009 Jun 24;6:86. PubMed PMID: 19552824; PubMed Central PMCID: PMC2706813.
  • Cantalupo PG, Sáenz-Robles MT, Rathi AV, Beerman RW, Patterson WH, Whitehead RH, Pipas JM. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009 Mar 30;386(1):183-91. Epub 2009 Feb 8. PubMed PMID: 19201438; PubMed Central PMCID: PMC2737743.
  • Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM, Brodsky JL. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. Epub 2009 Feb 4. PubMed PMID: 19200446; PubMed Central PMCID: PMC2758074.
  • Zhao X, Madden-Fuentes RJ, Lou BX, Pipas JM, Gerhardt J, Rigell CJ, Fanning E. Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. J Virol. 2008 Jun;82(11):5316-28. Epub 2008 Mar 19. PubMed PMID: 18353955; PubMed Central PMCID: PMC2395194.

Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM,
Pipas JM, Day BW, Wipf P, Brodsky JL. Pyrimidinone-peptoid hybrid molecules with
distinct effects on molecular chaperone function and cell proliferation. Bioorg
Med Chem. 2008 Mar 15;16(6):3291-301. Epub 2007 Dec 14. PubMed PMID: 18164205;
PubMed Central PMCID: PMC2330198.

Sáenz-Robles MT, Markovics JA, Chong JL, Opavsky R, Whitehead RH, Leone G,
Pipas JM. Intestinal hyperplasia induced by simian virus 40 large tumor antigen
requires E2F2. J Virol. 2007 Dec;81(23):13191-9. Epub 2007 Sep 12. PubMed PMID:
17855529; PubMed Central PMCID: PMC2169091.

Rathi AV, Sáenz Robles MT, Pipas JM. Enterocyte proliferation and intestinal
hyperplasia induced by simian virus 40 T antigen require a functional J domain. J
Virol. 2007 Sep;81(17):9481-9. Epub 2007 Jun 20. PubMed PMID: 17581980; PubMed
Central PMCID: PMC1951414.

Sáenz-Robles MT, Toma D, Cantalupo P, Zhou J, Gong H, Edwards C, Pipas JM,
Xie W. Repression of intestinal drug metabolizing enzymes by the SV40 large T
antigen. Oncogene. 2007 Aug 2;26(35):5124-31. Epub 2007 Mar 5. PubMed PMID:
17334401.

Wright CM, Fewell SW, Sullivan ML, Pipas JM, Watkins SC, Brodsky JL. The
Hsp40 molecular chaperone Ydj1p, along with the protein kinase C pathway, affects
cell-wall integrity in the yeast Saccharomyces cerevisiae. Genetics. 2007
Apr;175(4):1649-64. Epub 2007 Jan 21. PubMed PMID: 17237519; PubMed Central
PMCID: PMC1855118.

Cantalupo P, Doering A, Sullivan CS, Pal A, Peden KW, Lewis AM, Pipas JM.
Complete nucleotide sequence of polyomavirus SA12. J Virol. 2005
Oct;79(20):13094-104. PubMed PMID: 16189011; PubMed Central PMCID: PMC1235855.

Sullivan CS, Grundhoff AT, Tevethia S, Pipas JM, Ganem D. SV40-encoded
microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T
cells. Nature. 2005 Jun 2;435(7042):682-6. PubMed PMID: 15931223.

Markovics JA, Carroll PA, Robles MT, Pope H, Coopersmith CM, Pipas JM.
Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.
J Virol. 2005 Jun;79(12):7492-502. PubMed PMID: 15919904; PubMed Central PMCID:
PMC1143657.

Sullivan CS, Baker AE, Pipas JM. Simian virus 40 infection disrupts p130-E2F
and p107-E2F complexes but does not perturb pRb-E2F complexes. Virology. 2004 Mar
15;320(2):218-28. PubMed PMID: 15016545.

Genevaux P, Lang F, Schwager F, Vartikar JV, Rundell K, Pipas JM,
Georgopoulos C, Kelley WL. Simian virus 40 T antigens and J domains: analysis of
Hsp40 cochaperone functions in Escherichia coli. J Virol. 2003
Oct;77(19):10706-13. PubMed PMID: 12970459; PubMed Central PMCID: PMC228479.

Chromy LR, Pipas JM, Garcea RL. Chaperone-mediated in vitro assembly of
Polyomavirus capsids. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10477-82. Epub
2003 Aug 19. PubMed PMID: 12928495; PubMed Central PMCID: PMC193586.

Fewell SW, Pipas JM, Brodsky JL. Mutagenesis of a functional chimeric gene in
yeast identifies mutations in the simian virus 40 large T antigen J domain. Proc
Natl Acad Sci U S A. 2002 Feb 19;99(4):2002-7. PubMed PMID: 11854498; PubMed
Central PMCID: PMC122309.

Sachsenmeier KF, Pipas JM. Inhibition of Rb and p53 is insufficient for SV40
T-antigen transformation. Virology. 2001 Apr 25;283(1):40-8. PubMed PMID:
11312660.

Sullivan CS, Gilbert SP, Pipas JM. ATP-dependent simian virus 40
T-antigen-Hsc70 complex formation. J Virol. 2001 Feb;75(4):1601-10. PubMed PMID:
11160658; PubMed Central PMCID: PMC114069.

Rempel RE, Saenz-Robles MT, Storms R, Morham S, Ishida S, Engel A, Jakoi L,
Melhem MF, Pipas JM, Smith C, Nevins JR. Loss of E2F4 activity leads to abnormal
development of multiple cellular lineages. Mol Cell. 2000 Aug;6(2):293-306.
PubMed PMID: 10983977.

Sullivan CS, Cantalupo P, Pipas JM. The molecular chaperone activity of
simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by
an ATP-dependent mechanism. Mol Cell Biol. 2000 Sep;20(17):6233-43. PubMed PMID:
10938100; PubMed Central PMCID: PMC86098.

Sullivan CS, Tremblay JD, Fewell SW, Lewis JA, Brodsky JL, Pipas JM.
Species-specific elements in the large T-antigen J domain are required for
cellular transformation and DNA replication by simian virus 40. Mol Cell Biol.
2000 Aug;20(15):5749-57. PubMed PMID: 10891510; PubMed Central PMCID: PMC86052.

Slinskey A, Barnes D, Pipas JM. Simian virus 40 large T antigen J domain and
Rb-binding motif are sufficient to block apoptosis induced by growth factor
withdrawal in a neural stem cell line. J Virol. 1999 Aug;73(8):6791-9. PubMed
PMID: 10400777; PubMed Central PMCID: PMC112764.

Ibaraki N, Chen SC, Lin LR, Okamoto H, Pipas JM, Reddy VN. Human lens
epithelial cell line. Exp Eye Res. 1998 Nov;67(5):577-85. PubMed PMID: 9878220.

Higashino F, Pipas JM, Shenk T. Adenovirus E4orf6 oncoprotein modulates the
function of the p53-related protein, p73. Proc Natl Acad Sci U S A. 1998 Dec
22;95(26):15683-7. PubMed PMID: 9861030; PubMed Central PMCID: PMC28104.

Peden KW, Srinivasan A, Vartikar JV, Pipas JM. Effects of mutations within
the SV40 large T antigen ATPase/p53 binding domain on viral replication and
transformation. Virus Genes. 1998;16(2):153-65. PubMed PMID: 9608660.

Castellino AM, Cantalupo P, Marks IM, Vartikar JV, Peden KW, Pipas JM.
trans-Dominant and non-trans-dominant mutant simian virus 40 large T antigens
show distinct responses to ATP. J Virol. 1997 Oct;71(10):7549-59. PubMed PMID:
9311835; PubMed Central PMCID: PMC192102.

Srinivasan A, McClellan AJ, Vartikar J, Marks I, Cantalupo P, Li Y, Whyte P,
Rundell K, Brodsky JL, Pipas JM. The amino-terminal transforming region of simian
virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol.
1997 Aug;17(8):4761-73. PubMed PMID: 9234732; PubMed Central PMCID: PMC232328.

Rushton JJ, Jiang D, Srinivasan A, Pipas JM, Robbins PD. Simian virus 40 T
antigen can regulate p53-mediated transcription independent of binding p53. J
Virol. 1997 Jul;71(7):5620-3. PubMed PMID: 9188637; PubMed Central PMCID:
PMC191805.

Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA,
Roberts TM, Schaffhausen BS, DeCaprio JA. DnaJ/hsp40 chaperone domain of SV40
large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May
1;11(9):1098-110. PubMed PMID: 9159391.

Collins BS, Pipas JM. T antigens encoded by replication-defective simian
virus 40 mutants dl1135 and 5080. J Biol Chem. 1995 Jun 23;270(25):15377-84.
PubMed PMID: 7797527.

Okamoto S, Ohji M, Kosaku K, Sundarraj N, Hassell JR, Thoft RA, Pipas JM.
Characterization of immortalized rabbit corneal epithelial cells with SV40 large
T antigen. Jpn J Ophthalmol. 1995;39(4):323-33. PubMed PMID: 8926638.

Spence SL, Pipas JM. SV40 large T antigen functions at two distinct steps in
virion assembly. Virology. 1994 Oct;204(1):200-9. PubMed PMID: 8091652.

Kim SH, Roth KA, Coopersmith CM, Pipas JM, Gordon JI. Expression of wild-type
and mutant simian virus 40 large tumor antigens in villus-associated enterocytes
of transgenic mice. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6914-8. PubMed
PMID: 8041720; PubMed Central PMCID: PMC44308.

Spence SL, Pipas JM. Simian virus 40 large T antigen host range domain
functions in virion assembly. J Virol. 1994 Jul;68(7):4227-40. PubMed PMID:
8207798; PubMed Central PMCID: PMC236346.

Quartin RS, Cole CN, Pipas JM, Levine AJ. The amino-terminal functions of the
simian virus 40 large T antigen are required to overcome wild-type p53-mediated
growth arrest of cells. J Virol. 1994 Mar;68(3):1334-41. PubMed PMID: 8107198;
PubMed Central PMCID: PMC236587.

Finley GG, Koski RA, Melhem MF, Pipas JM, Meisler AI. Expression of the
gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res.
1993 Jun 15;53(12):2919-26. PubMed PMID: 8504433.

Symonds HS, McCarthy SA, Chen J, Pipas JM, Van Dyke T. Use of transgenic mice
reveals cell-specific transformation by a simian virus 40 T-antigen
amino-terminal mutant. Mol Cell Biol. 1993 Jun;13(6):3255-65. PubMed PMID:
8388535; PubMed Central PMCID: PMC359774.

Mack DH, Vartikar J, Pipas JM, Laimins LA. Specific repression of
TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature.
1993 May 20;363(6426):281-3. PubMed PMID: 8387645.

Melhem MF, Meisler AI, Finley GG, Bryce WH, Jones MO, Tribby II, Pipas JM,
Koski RA. Distribution of cells expressing myc proteins in human colorectal
epithelium, polyps, and malignant tumors. Cancer Res. 1992 Nov 1;52(21):5853-64.
PubMed PMID: 1394214.

Chen J, Tobin GJ, Pipas JM, Van Dyke T. T-antigen mutant activities in vivo:
roles of p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene.
1992 Jun;7(6):1167-75. PubMed PMID: 1317542.

Peden KW, Pipas JM. Simian virus 40 mutants with amino-acid substitutions
near the amino terminus of large T antigen. Virus Genes. 1992 Apr;6(2):107-18.
PubMed PMID: 1317074.

Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM.
Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a
cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol. 1991
Aug;11(8):3842-9. PubMed PMID: 1712897; PubMed Central PMCID: PMC361167.

Yaciuk P, Carter MC, Pipas JM, Moran E. Simian virus 40 large-T antigen
expresses a biological activity complementary to the p300-associated transforming
function of the adenovirus E1A gene products. Mol Cell Biol. 1991
Apr;11(4):2116-24. PubMed PMID: 1848672; PubMed Central PMCID: PMC359899.

Spence SL, Tack LC, Wright JH, Carswell S, Pipas JM. Infection of CV1 cells
expressing the polyoma virus middle T antigen or the SV40 agnogene product with
simian virus 40 host-range mutants. In Vitro Cell Dev Biol. 1990
Jun;26(6):604-11. PubMed PMID: 2162817.

Peden KW, Spence SL, Tack LC, Cartwright CA, Srinivasan A, Pipas JM. A DNA
replication-positive mutant of simian virus 40 that is defective for
transformation and the production of infectious virions. J Virol. 1990
Jun;64(6):2912-21. PubMed PMID: 2159552; PubMed Central PMCID: PMC249475.

Dyson N, Bernards R, Friend SH, Gooding LR, Hassell JA, Major EO, Pipas JM,
Vandyke T, Harlow E. Large T antigens of many polyomaviruses are able to form
complexes with the retinoblastoma protein. J Virol. 1990 Mar;64(3):1353-6. PubMed
PMID: 2154613; PubMed Central PMCID: PMC249255.

Ludlow JW, Shon J, Pipas JM, Livingston DM, DeCaprio JA. The retinoblastoma
susceptibility gene product undergoes cell cycle-dependent dephosphorylation and
binding to and release from SV40 large T. Cell. 1990 Feb 9;60(3):387-96. PubMed
PMID: 2154332.

Srinivasan A, Peden KW, Pipas JM. The large tumor antigen of simian virus 40
encodes at least two distinct transforming functions. J Virol. 1989
Dec;63(12):5459-63. PubMed PMID: 2555566; PubMed Central PMCID: PMC251216.

Tack LC, Cartwright CA, Wright JH, Eckhart W, Peden KW, Srinivasan A, Pipas
JM. Properties of a simian virus 40 mutant T antigen substituted in the
hydrophobic region: defective ATPase and oligomerization activities and altered
phosphorylation accompany an inability to complex with cellular p53. J Virol.
1989 Aug;63(8):3362-7. PubMed PMID: 2545911; PubMed Central PMCID: PMC250910.

Cartwright CA, Kamps MP, Meisler AI, Pipas JM, Eckhart W. pp60c-src
activation in human colon carcinoma. J Clin Invest. 1989 Jun;83(6):2025-33.
PubMed PMID: 2498394; PubMed Central PMCID: PMC303927.

Finley GG, Schulz NT, Hill SA, Geiser JR, Pipas JM, Meisler AI. Expression of
the myc gene family in different stages of human colorectal cancer. Oncogene.
1989 Aug;4(8):963-71. PubMed PMID: 2668847.

Peden KW, Srinivasan A, Farber JM, Pipas JM. Mutants with changes within or
near a hydrophobic region of simian virus 40 large tumor antigen are defective
for binding cellular protein p53. Virology. 1989 Jan;168(1):13-21. PubMed PMID:
2535898.

Hunter LA, Pipas JM. Isolation of a simian virus 40-simian agent 12
recombinant papovavirus that synthesizes a hybrid large tumour antigen. J Gen
Virol. 1988 Mar;69 ( Pt 3):683-7. PubMed PMID: 2832530.

Khalili K, Brady J, Pipas JM, Spence SL, Sadofsky M, Khoury G.
Carboxyl-terminal mutants of the large tumor antigen of simian virus 40: a role
for the early protein late in the lytic cycle. Proc Natl Acad Sci U S A. 1988
Jan;85(2):354-8. PubMed PMID: 2829182; PubMed Central PMCID: PMC279546.

Tevethia MJ, Pipas JM, Kierstead T, Cole C. Requirements for immortalization
of primary mouse embryo fibroblasts probed with mutants bearing deletions in the
3′ end of SV40 gene A. Virology. 1988 Jan;162(1):76-89. PubMed PMID: 2827389.

Michalovitz D, Fischer-Fantuzzi L, Vesco C, Pipas JM, Oren M. Activated
Ha-ras can cooperate with defective simian virus 40 in the transformation of
nonestablished rat embryo fibroblasts. J Virol. 1987 Aug;61(8):2648-54. PubMed
PMID: 3037122; PubMed Central PMCID: PMC255717.

Chiang LC, Silnutzer J, Pipas JM, Barnes DW. Selection of transformed cells
in serum-free media. In Vitro Cell Dev Biol. 1985 Dec;21(12):707-12. PubMed PMID:
3001020.

Cunningham TP, Pipas JM. Simian agent 12 is a BK virus-like papovavirus which
replicates in monkey cells. J Virol. 1985 May;54(2):483-92. PubMed PMID: 2985810;
PubMed Central PMCID: PMC254820.

Pipas JM. Mutations near the carboxyl terminus of the simian virus 40 large
tumor antigen alter viral host range. J Virol. 1985 May;54(2):569-75. PubMed
PMID: 2985819; PubMed Central PMCID: PMC254830.

Peden KW, Pipas JM. Site-directed mutagenesis of the simian virus 40 large
T-antigen gene: replication-defective amino acid substitution mutants that retain
the ability to induce morphological transformation. J Virol. 1985 Jul;55(1):1-9.
PubMed PMID: 2989548; PubMed Central PMCID: PMC254890.

Clark R, Peden K, Pipas JM, Nathans D, Tjian R. Biochemical activities of
T-antigen proteins encoded by simian virus 40 A gene deletion mutants. Mol Cell
Biol. 1983 Feb;3(2):220-8. PubMed PMID: 6300658; PubMed Central PMCID: PMC368525.

Soprano KJ, Galanti N, Jonak GJ, McKercher S, Pipas JM, Peden KW, Baserga R.
Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA
synthesis and activation of rRNA genes by mutants with deletions in the T-antigen
gene. Mol Cell Biol. 1983 Feb;3(2):214-9. PubMed PMID: 6300657; PubMed Central
PMCID: PMC368524.

Pipas JM, Peden KW, Nathans D. Mutational analysis of simian virus 40 T
antigen: isolation and characterization of mutants with deletions in the
T-antigen gene. Mol Cell Biol. 1983 Feb;3(2):203-13. PubMed PMID: 6300656; PubMed
Central PMCID: PMC368523.

Wilson JH, Berget PB, Pipas JM. Somatic cells efficiently join unrelated DNA
segments end-to-end. Mol Cell Biol. 1982 Oct;2(10):1258-69. PubMed PMID: 6294502;
PubMed Central PMCID: PMC369925.

Peden KW, Pipas JM, Pearson-White S, Nathans D. Isolation of mutants of an
animal virus in bacteria. Science. 1980 Sep 19;209(4463):1392-6. PubMed PMID:
6251547.

Pipas JM, Reeves RH. Host transcription in bacteriophage P22-infected
Salmonella typhimurium. J Virol. 1979 Dec;32(3):822-31. PubMed PMID: 390166;
PubMed Central PMCID: PMC525930.

Pipas JM, Reeves RH. Patterns of transcription in bacteriophage P22-infected
Salmonella typhimurium. J Virol. 1977 Feb;21(2):825-8. PubMed PMID: 319258;
PubMed Central PMCID: PMC353888.

Pipas JM, McMahon JE. Method for predicting RNA secondary structure. Proc
Natl Acad Sci U S A. 1975 Jun;72(6):2017-21. PubMed PMID: 1056009; PubMed Central
PMCID: PMC432683.