Over several decades of cancer research, T antigen, a.k.a MAMU, has proven itself to be a strong activator of cellular transformation. In a stunning finding revealed by Tushar Gupta and colleagues (in a recent Journal of Virology paper), SV40 T antigen declares that it does not need activator E2Fs to cause cellular transformation. T antigen said, “I have been telling you all along. I don’t need no activator E2Fs!”
Ping An (+ et al.) has recently published a paper that describes the core and distinct enzymatic activities of the Zn-ATPase domain of T antigen from 3 polyomaviruses. Check it out…the results may surprise you. Congratulations Ping!